The Hypoxic Placenta
نویسندگان
چکیده
منابع مشابه
Magnetic resonance imaging of hypoxic injury to the murine placenta.
We assessed the use of magnetic resonance imaging (MRI) to define placental hypoxic injury associated with fetal growth restriction. On embryonic day 18.5 (E18.5) we utilized dynamic contrast-enhanced (DCE)-MRI on a 4.7-tesla small animal scanner to examine the uptake and distribution of gadolinium-based contrast agent. Quantitative DCE parameter analysis was performed for the placenta and feta...
متن کاملPlacenta growth factor and vascular endothelial growth factor B expression in the hypoxic lung
BACKGROUND Chronic alveolar hypoxia, due to residence at high altitude or chronic obstructive lung diseases, leads to pulmonary hypertension, which may be further complicated by right heart failure, increasing morbidity and mortality. In the non-diseased lung, angiogenesis occurs in chronic hypoxia and may act in a protective, adaptive manner. To date, little is known about the behaviour of ind...
متن کاملI-7: Maternal Signalling to the Placenta
Background: Though it is well established that maternal blood-borne signals influence highly the growth of the placenta, the mechanisms are not known. In vitro trophoblast culture models are limited by an inability to reconstruct the polarised bilayer of the human hemochorial placenta. We have used a first trimester villous tissue explant system to investigate how growth factors interact with p...
متن کاملSuppression of Mitochondrial Electron Transport Chain Function in the Hypoxic Human Placenta: A Role for
Fetal growth is critically dependent on energy metabolism in the placenta, which drives active exchange of nutrients. Placental oxygen levels are therefore vital, and chronic hypoxia during pregnancy impairs fetal growth. Here we tested the hypothesis that placental hypoxia alters mitochondrial electron transport chain (ETS) function, and sought to identify underlying mechanisms. We cultured hu...
متن کاملTherapeutic effect of placenta-derived mesenchymal stem cells on hypoxic-ischemic brain damage in rats.
BACKGROUND Oxidative stress is involved in the development of hypoxic-ischemic brain damage (HIBD). In this study, we investigated the therapeutic effects of placenta-derived mesenchymal stem cells (PD-MSCs) and explored the NF-E2-related factor-2/heme oxygenase-1 (Nrf2/HO-1) signaling pathway in treating HIBD. METHODS P7 rats were subjected to hypoxic-ischemic brain injury and randomly divid...
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ژورنال
عنوان ژورنال: High Altitude Medicine & Biology
سال: 2012
ISSN: 1527-0297,1557-8682
DOI: 10.1089/ham.2012.1046